Tumor Supressor Genes in Cancer Therapy,9780896038073

Tumor Supressor Genes in Cancer Therapy

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ISBN13: 9780896038073
ISBN10: 0896038076
Format: Hardcover
Pub. Date: 2000-11-01
Publisher(s): Humana Pr Inc
List Price: $293.99

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Summary

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Table of Contents

Preface v
Contributors xi
Part I. Analysis and Clinical Implications of Tumor Suppressor Genes
Animal Models for Tumor Suppressor Genes
3(26)
Jordan A. Kreidberg
Thomas A. Natoli
Viral Oncoproteins as Probes for Tumor Suppressor Function
29(20)
Srikumar P. Chellappan
Tumor Suppressors in Metastasis
49(30)
Taoufik Ouatas
Melanie T. Hartsough
Patricia S. Steeg
Apoptosis: Machinery of Cell Death in Development and Cancer
79(24)
Jinyan Du
David E. Fisher
Drug Discovery in Oncology
103(28)
Alex Matter
Part II. Tumor Suppressor Pathways
Retinoblastoma Protein in Growth Control and Differentiation
131(28)
Lilia Stepanova
J. Wade Harper
p53 Tumor Suppressor Protein
159(24)
Margaret Ashcroft
Karen H. Vousden
p16 Tumor Suppressor
183(14)
Alexander Kamb
Ken McCormack
DNA Mismatch Repair in Tumor Suppression
197(34)
Guo-Min Li
Scott McCulloch
Liya Gu
PTEN: Regulator of Phosphoinositide 3-Kinase Signal Transduction
231(22)
Jen Jen Yeh
William R. Sellers
Neurofibromatoses
253(28)
Andre Bernards
Andrea I. McClatchey
Von Hippel-Lindau Disease: Clinical and Molecular Aspects
281(26)
Othon Iliopoulos
William G. Kaelin, Jr.
Wilms' Tumor: A Developmental Anomaly
307(44)
Aswin L. Menke
Nick D. Hastie
Fanconi Anemia Pathway and Cancer Susceptibility
351(20)
Yanan Kuang
Irene Garcia-Higuera
Eric Nisbet-Brown
Anna Savoia
Alan D. D' Andrea
Index 371

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