The current book can be studied together with the texbook Statistics Applied To Clinical Trials by the same authors, or separately. The authors often hear that students have difficulties in understanding statistics from a textbook and that self-assessment through exercises and examples is required. Rather than trying to be complete, this book focuses on the main aspects, including the test statistics generally used for the primary analysis of continuous and proportional data from randomized controlled clinical trials. In the past few years statistical analysis has increasingly been left to the computer, and clinical investigators are at a loss to understand the limitations of the research and its statistical analysis, on the one hand, while on the other hand, statistical results are often overemphasized. This self-assessment book is not only useful for investigators involved in the field of clinical trials, but also for every physician who wishes to better understand the data from trials as published currently.

Ton J. Cleophas, MD, PhD, Associate-Professor, President American College of Angiology, Co-Chair Module Statistics Applied to Clinical Trials, European Interuniversity College of Pharmaceutical Medicine Lyon, France, Internist-clinical pharmacologist, Department Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands Aeilko H. Zwinderman, Math D, PhD, Professor, Co-Chair Module Statistics Applied to Clinical Trials, European Interuniversity College of Pharmaceutical Medicine Lyon, France, Professor of Statistics, Department Biostatistics and Epidemiology, Academic Medical Center Amsterdam, Netherlands Toine F. Cleophas, D Techn, Technical University, Delft, Netherlands