Dermatopathology: The Basics
by Smoller, Bruce R., M.D.Edition: 1st
Format: Paperback
Pub. Date: 2009-06-01
Publisher(s): SPRINGER
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Summary
Dermatopathology: The Basics will serve as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities.
Author Biography
Bruce R. Smoller, MD is Aubrey J. Hough, Jr. MD Endowed Chair of Pathology, Department Chair and Professor in Pathology and Dermatology, University of Arkansas of Medical Sciences, Little Rock, Arkansas. Kim M. Hiatt, MD is Associate Professor, Director Dermatopathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Table of Contents
| Normal Cutaneous Histology | p. 1 |
| Basic Skin Anatomy | p. 1 |
| Epidermis | p. 1 |
| Keratinocytes | p. 1 |
| Melanocytes | p. 5 |
| Langerhans Cells | p. 6 |
| Merkel Cells | p. 8 |
| Epidermal Appendages | p. 8 |
| Basement Membrance Zone | p. 17 |
| Basal Keratinocyte | p. 18 |
| Lamina Lucida | p. 18 |
| Lamina Densa | p. 19 |
| Sub lamina Densa | p. 19 |
| Dermis | p. 19 |
| Vasculature | p. 20 |
| Nerves | p. 24 |
| Muscles | p. 26 |
| Subcutaneous Fat | p. 29 |
| Skin of "Special Sites" | p. 30 |
| How to Maximize Information from a Skin Biopsy | p. 37 |
| Presumed Neoplastic Processes | p. 38 |
| What is the Differential Diagnosis? | p. 38 |
| Are the Margins Important? | p. 39 |
| Melanocytic Neoplasms | p. 40 |
| Keratinocytic Neoplasms | p. 41 |
| Adnexal Neoplasms | p. 43 |
| Dermal Neoplasms | p. 46 |
| Hematopoietic Neoplasms | p. 49 |
| Inflammatory Processes | p. 50 |
| Blistering Diseases | p. 50 |
| "Dermatitis" and "Rash" | p. 52 |
| Infectious diseases | p. 53 |
| Connective Tissue Diseases | p. 56 |
| Direct Immunofluorescence | p. 57 |
| Vasculitis | p. 57 |
| Panniculitis | p. 58 |
| Alopecia | p. 59 |
| Miscellaneous Conditions | p. 60 |
| Presumed Connective Tissue Nevus, Anetoderma, Epidermal Nevus | p. 60 |
| Rules of Thumb | p. 61 |
| Special Stains in Dermatopathology | p. 63 |
| Histochemical Stains | p. 63 |
| Commonly Used Special Stains | p. 63 |
| Periodic Acid-Schiff (PAS) | p. 64 |
| PAS Uses | p. 64 |
| Alcian Blue | p. 64 |
| Alcian Blue/Colloidal Iron Uses | p. 65 |
| Elastic von Gieson | p. 65 |
| Von Gieson Uses | p. 65 |
| Brown and Brenn Stain | p. 66 |
| Acid Fast Stain (AFB) | p. 67 |
| Fite Stain | p. 67 |
| Giemsa | p. 67 |
| Giemsa Uses | p. 67 |
| Warthin-Starry | p. 68 |
| Masson's Trichrome | p. 69 |
| Congo Red | p. 70 |
| Fontana Stain For Melanin | p. 71 |
| Chloroacetate Esterase | p. 71 |
| Perls | p. 72 |
| Immunopathology in Diagnostic Dermatopathology | p. 75 |
| Tool Box: Antibody Panel | p. 75 |
| What Is a Tool Box? | p. 75 |
| Epithelial Markers | p. 75 |
| Mesenchymal Markers | p. 78 |
| Neuroectodermal Markers | p. 79 |
| Hematopoietic Markers | p. 81 |
| Miscellaneous Markers | p. 84 |
| Requirements for Interpretation | p. 85 |
| Pitfalls in Interpretation | p. 86 |
| Strategy for Immunopathology | p. 87 |
| Immunopathology | p. 88 |
| Differential Diagnosis of Normal Skin | p. 93 |
| Tinea Versicolor | p. 94 |
| Ichthyoses | p. 96 |
| Ichthyosis (X-Linked) | p. 96 |
| Ichthyosis (Lamellar) | p. 97 |
| Erythrasma | p. 98 |
| Ichthyosis Vulgaris | p. 100 |
| Pemphigus Foliaceus/Erythematosus | p. 101 |
| Vitiligo | p. 102 |
| Café-Au-Lait Macule | p. 104 |
| Nevus Depigmentosus (Nevus Achromicus) | p. 105 |
| Connective Tissue Nevus | p. 106 |
| Cutis Laxa | p. 108 |
| Morphea | p. 110 |
| Anetoderma (Macular Atrophy, Focal Dermal Elastolysis) | p. 113 |
| Wrinkling due to Mid-dermal Elastolysis | p. 114 |
| Dermal Deposition Disorders | p. 114 |
| Amyloidosis | p. 115 |
| Localized Cutaneous Amyloidosis | p. 115 |
| Pretibial Myxedema | p. 117 |
| Sclerodema | p. 119 |
| Scleromyxedema | p. 121 |
| Nephrogenic Systemic Fibrosis | p. 122 |
| Conditions with Minimal Inflammation | p. 124 |
| Small Plaque (Guttate) Parapsoriasis (Digitate Dermatosis) | p. 124 |
| Urticaria | p. 126 |
| Urticaria Pigmentosa | p. 126 |
| Further Reading | p. 129 |
| Index | p. 139 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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