Summary
Cell Therapy, Stem Cells, and Brain Repair reviews the most compelling treatments for neurodegenerative diseases, disorders, and injuries, including Parkinson's disease, Huntington's disease, traumatic brain injury, and stroke. Covering the history of cell therapy and neural transplantation, it also focuses on stem cells, including embryonic, bone marrow, and umbilical cord blood, as well as other investigative sources. This compilation explicates previous cornerstones and milestones of neurological cellular therapy, which have provided a foundation for modern stem cell research. In Cell Therapy, Stem Cells, and Brain Repair, the challenges and current direction of cellular research are described in great detail. Modern techniques involving certain subsets of cell populations are also explained. In addition, the ongoing discovery of stem cell sources for cell therapy is discussed, while expounding upon clinical applications for cellular therapeutic brain repair as certain cells become increasingly promising. Explaining the field of cell therapy from a scientific, clinical, and ethical perspective, Cell Therapy, Stem Cell, and Brain Repair is essential reading for neurologists, scientists, and clinicians looking to stay on the cutting-edge of regenerative medicine.
Table of Contents
Preface |
|
v | |
Contributors |
|
xiii | |
Color Plates |
|
xvi | |
|
Current Views of the Embryonic and Neural Stem Cell: Cell Replacement or Molecular Repair? |
|
|
1 | (30) |
|
|
|
|
|
|
Developing Novel Cell Sources for Transplantation in Parkinson's Disease |
|
|
31 | (30) |
|
Nicolaj S. Christophersen |
|
|
|
|
|
|
Neural Transplantation in the Nonhuman Primate Model of Parkinson's Disease |
|
|
61 | (22) |
|
|
|
Cell-Based Therapy for Huntington's Disease |
|
|
83 | (34) |
|
|
|
|
Use of Bone Marrow Stem Cells as Therapy for Behavioral Deficits in Rodent Models of Huntington's Disease |
|
|
117 | (22) |
|
|
|
|
Human Neuroteratocarcinoma Cells as a Neural Progenitor Graft Source for Cell Transplantation in Stroke |
|
|
139 | (24) |
|
|
|
|
|
Therapeutic Applications of Bone Marrow-Derived Stem Cells in Neurologic Injury and Disease |
|
|
163 | (36) |
|
|
|
|
|
|
Cell Therapy for Models of Pain and Traumatic Brain Injury |
|
|
199 | (42) |
|
|
|
The Use of Sertoli Cells in Neural Transplantation |
|
|
241 | (20) |
|
|
|
|
The Choroid Plexus: A Novel Graft Source for Neural Transplantation |
|
|
261 | (26) |
|
|
|
|
|
|
Progress and Challenges in Immunoisolation for CNS Cell Therapy |
|
|
287 | (38) |
|
|
|
Evidence-Based Methodology for Advancing Neural Reconstruction |
|
|
325 | (16) |
|
|
Hematopoietic Cell Therapy for Brain Repair |
|
|
341 | (22) |
|
|
|
Stem Cells and Regenerative Medicine: Commercial and Pharmaceutical Implications |
|
|
363 | (22) |
|
|
Index |
|
385 | |