Organic Chemistry, 4th Edition provides a comprehensive yet accessible treatment of all the essential organic chemistry concepts covered in a two-semester course. Presenting a skills-based approach that bridges the gap between organic chemistry theory and real-world practice, Dr. David Klein makes content comprehensible to students while placing special emphasis on developing their problem-solving skills through applied exercises and activities. This edition is available with the new and improved WileyPLUS—an immersive online environment packed with interactive study tools, strategies, and resources that support different learning styles.

Organic Chemistry incorporates Klein's acclaimed SkillBuilder program which supplies a wealth of opportunities for students to develop the key skills necessary to succeed in organic chemistry. Each SkillBuilder contains a solved problem that demonstrates a skill and several practice problems of varying difficulty levels—including conceptual and cumulative problems that challenge students to apply the skill in a slightly different environment. An up-to-date collection of literature-based problems exposes students to the dynamic and evolving nature of organic chemistry and its active role in addressing global challenges. Throughout the text, numerous hands-on activities and real-world examples help students understand both the "why" and the "how" behind organic chemistry.

1 A Review of General Chemistry: Electrons, Bonds, and Molecular Properties 1

2 Molecular Representations 50

3 Acids and Bases 93

4 Alkanes and Cycloalkanes 138

5 Stereoisomerism 188

6 Chemical Reactivity and Mechanisms 233

7 Alkyl Halides: Nucleophilic Substitution and Elimination Reactions 280

8 Addition Reactions of Alkenes 356

9 Alkynes 417

10 Radical Reactions 454

11 Synthesis 499

12 Alcohols and Phenols 529

13 Ethers and Epoxides; Thiols and Sulfides 585

14 Infrared Spectroscopy and Mass Spectrometry 636

15 Nuclear Magnetic Resonance Spectroscopy 684

16 Conjugated Pi Systems and Pericyclic Reactions 738

17 Aromatic Compounds 788

18 Aromatic Substitution Reactions 828

19 Aldehydes and Ketones 884

20 Carboxylic Acids and Their Derivatives 938

21 Alpha Carbon Chemistry: Enols and Enolates 996

22 Amines 1054

23 Introduction to Organometallic Compounds 1100

24 Carbohydrates 1153

25 Amino Acids, Peptides, and Proteins 1194

26 Lipids 1238

27 Synthetic Polymers 1277